Transforming growth factor-β: A therapeutic target for cancer
نویسندگان
چکیده
منابع مشابه
Transforming growth factor-β as a therapeutic target in hepatocellular carcinoma.
Hepatocellular carcinoma arises in patients as a consequence of long-standing preexisting liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. In such preexisting liver diseases, TGF-β plays an important role in orchestrating a favorable microenvironment for tumor cell growth and promoting epithelial-mesenchymal transition (EMT). TGF-β signaling promotes hepatocellul...
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Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular re...
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Dna2 was first characterized in yeast as an essential gene encoding a protein with both helicase and endonuclease activities involved in maturation of Okazaki fragments during DNA replication. Dna2 also plays a role in double-strand break (DSB) repair by homolo-gous recombination. The respective contributions of its replication and/or repair functions toward cell viability and resistance to gen...
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Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...
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Human tumours have evolved intricate mechanisms to evade the immune system, either by avoiding recognition or by inhibiting and eliminating immune cells. Although clear evidence exists that the immune system is mobilized in response to tumour growth—a fact that is manifested in the accumulation of numerous immune cells including dendritic cells (DCs), natural killer (NK) cells, macrophages, and...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2017
ISSN: 2164-5515,2164-554X
DOI: 10.1080/21645515.2017.1327107